One-Pot Synthesis of 2,3-Dioxopyrrolidine Derivatives as Potential Anti-MRSA Agents

Abstract

The rapid global spread of methicillin-resistant Staphylococcus aureus (MRSA) has become a serious public health concern due to its resistance to methicillin and most β-lactam antibiotics. The continuous rise of resistant strains has significantly limited current treatment options, emphasizing the urgent need for new antibacterial agents. Heterocyclic compounds are well-established scaffolds in medicinal chemistry due to their diverse biological activities. Among them, 2,3-dioxopyrrolidines possess structural similarity to biologically active pyrrolidine-based compounds and have demonstrated promising antimicrobial potential. However, studies combining environmentally friendly synthesis routes with anti-MRSA evaluation of 2,3-dioxopyrrolidine derivatives remain limited. This study aims to develop a one-pot synthetic approach for 2,3-dioxopyrrolidine derivatives following green chemistry principles while providing a foundation for future antibacterial evaluation.