Synthesis, Characterization and Anti-Bacterial Study of Ni(II) and Co(II) Schiff Base Complexes

Abstract

Antibiotic-resistant bacteria are a growing global concern. There is an urgent need to synthesize new antibacterial agents, especially those from Schiff base ligands and their complexes, due to their promising antibiotic potential. Schiff bases are made through a condensation reaction between carbonyl compounds (o-vanillin and chlorobenzaldehyde) and an amine (o-phenylenediamine), forming an imine (C=N) that replaces the original carbonyl group. The presence of donor atoms (ONNO) makes them highly attractive for pharmaceuticals. Transition metal complexes, particularly Ni(II) and Co(II), also attract attention in medicine as metal coordination often boosts biological activity.