Synthesis of Betulinic Acid-2-Hydroxy-5-Methoxybenzylidene Hydrazone

Abstract

Betulinic acid is a natural pentacyclic triterpenoid with notable pharmaceutical and therapeutic properties, including anticancer, antiviral, anti-inflammatory, and antimicrobial activities. However, its potential is limited by poor solubility, low bioavailability, and low extraction yield from natural sources. To enhance its biological potential, the synthesis of novel derivatives is necessary.