Antifungal Activities of Ziziphus mauritiana against Candida albicans: In Vitro Study

Authors

  • HB Said Gulam Khan Centre of Preclinical Science Studies Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Selangor, Malaysia
  • NI Mohd Sarmin Centre of Preclinical Science Studies Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Selangor, Malaysia
  • MH Arzmi Kulliyyah of Dentistry, International Islamic University, Kuantan Campus, Bandar Indera Mahkota, 25200 Kuantan Pahang, Malaysia
  • HF Amiruddin Centre of Preclinical Science Studies Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Selangor, Malaysia
  • AA Mohd Radzi Centre of Preclinical Science Studies Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Selangor, Malaysia

DOI:

https://doi.org/10.24191/cos.v7i0.17489

Keywords:

antifungal, Ziziphus mauritiana, Candida albicans, plant extract

Abstract

Medicinal plants have been discovered and used in traditional medicine and pharmaceutical industries since centuries. In the current study, Ziziphus mauritiana leaves was used as it is rich with many biological active compounds such as flavonoids, polyphenols, sapronins and tanins. Previous studies reported the antibacterial and antifungal effects of Z. mauritiana towards various microorganisms. However, the antifungal activities of Z. mauritiana methanol extracts on Candida albicans (Clinical and American Type Culture Collection Strains) have not been discovered extensively.

Objectives: Therefore, the aim of the current study is to investigate the antifungal activity of Z. mauritiana leaves methanol extracts against C. albicans ATCC strain and clinical isolate (from oral cancer patient).

Methods: Antifungal susceptibility test (AST) was performed using disc diffusion, minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) to determine the antifungal activity of methanol leaves extract of Ziziphus mauritiana against C. albicans ATCC and clinical isolates.

Results: The results obtained showed that there is no zone of inhibition seen from disk diffusion test for both strains. However, the minimal inhibitory and minimal fungicidal concentration showed that Ziziphus mauritiana methanol extracts was able to inhibit C. albicans clinical isolate but not ATCC strain at 500mg/mL.

Conclusion: The finding of this study suggests that that Ziziphus mauritiana leaves methanol extract showed promising results against Candida albicans. Thus, it can be used as a source for functional ingredients for pharmaceutical drug industries in-order to reduce or inhibit oral fungal infection.

Downloads

Published

2020-09-01

How to Cite

Said Gulam Khan, H., Mohd Sarmin, N., Arzmi, M., Amiruddin, H., & Mohd Radzi, A. (2020). Antifungal Activities of Ziziphus mauritiana against Candida albicans: In Vitro Study. Compendium of Oral Science, 7, 1–12. https://doi.org/10.24191/cos.v7i0.17489

Issue

Vol. 7 (2020): Compendium of Oral Science

Section

Original Article

License

Copyright (c) 2024 Compendium of Oral Science

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Materials contained in the journal may be reproduced for educational purposes provided that both the author(s) and the journal are appropriately recognised; otherwise duplication is not permitted. No articles, reports, or portions there of may be translated into other languages, published in books, journals, magazines, or any other print form without written permission from the authors and from the journal.

Disclaimer: The statements, opinions and data expressed in the articles and reports herein are those of the author(s) and not of the publisher and the editor(s). The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any schemes, methods, instructions or ideas referred to in the content.