Detection of Metabolomic Profile of Saliva in Healthy Malaysian Adults

Authors

  • HL Han Hospital Sultan Haji Ahmad Shah, Jalan Maran 28000 Temerloh, Pahang, Malaysia
  • CY Lee Bundaberg Base Hospital, Bundaberg West, Queensland 4670, Australia
  • Y Shoji Faculty of Dentistry, Universiti Teknologi MARA Sg. Buloh Campus, Jalan Hospital, 47000 Sungai Buloh, Malaysia
  • HT Chin Bruker (Malaysia) Sdn Bhd, 303, Block A, Mentari Business Park, 46150 Petaling Jaya, Selangor, Malaysia

DOI:

https://doi.org/10.24191/cos.v2i0.17525

Keywords:

NMR, healthy adult, saliva, metabolomics

Abstract

Background: Saliva is a readily accessible biofluid that is important for the overall quality of life, functionally essential in the chewing, swallowing, tasting, regulation mouth flora and prevention of caries. The aim of this study is to assess the global metabolomic profile of saliva in healthy Malaysian adults. Methods: As a first step to determining and understanding the metabolomic profile of saliva in healthy Malaysian adults, we have collected saliva samples of 50 adults and measured the salivary metabolite to establish a profiling metabolite data, Human Metabolome Database (HMDB). Metabolites concentrations of saliva in healthy subjects were measured by using 1H NMR spectroscopy. Results: The results showed there was no significant inter-individual variations of the key metabolites observed among the healthy Malaysian adults and there was no significant variation of the metabolites between female and male subjects. Conclusion: The metabolomic profile of saliva in healthy Malaysian adults could be used to establish the metabolomic database and used as a comparison for future study of the saliva of specific diseases.

Compendium of Oral Science Cover 2015

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Published

2015-09-01

How to Cite

Han, H., Lee, C., Shoji, Y., & Chin, H. (2015). Detection of Metabolomic Profile of Saliva in Healthy Malaysian Adults. Compendium of Oral Science, 2, 40–46. https://doi.org/10.24191/cos.v2i0.17525

Issue

Vol. 2 (2015): Compendium of Oral Science

Section

Original Article

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