Acetylcholinesterase Activity and Histopathological Effect of Caffeine in Spleen of Plasmodium berghei ANKA-infected ICR Mice

Abstract

Malaria has been a significant health concern in Peninsular Malaysia since 2015. Despite a decrease in the number of cases, the disease remains troubling, with an unexpected occurrence of 4,000 to 5,000 cases annually. Antimalarial drug resistance has led to higher rates of morbidity and mortality, weakening efforts to control the disease. Hence plant-based compound like caffeine was explored as a potential drug to treat malaria. The association between caffeine and malaria has been studied, particularly for its potential to improve the efficacy of antimalarial medications. This study aims to determine the AChE activity and the histopathological effects of caffeine on the spleen of malarial infected mice.