Antibiofilm Activity of Senna alata Against Pathogenic Bacteria and Fungi

Abstract

Biofilms are complex microbial communities encased in extracellular polymeric substances, posing significant health risks due to their resistance to conventional treatments and their role in various infections, including those linked to medical devices and tissues. Biofilm formation involves several steps: bacterial attachment, growth, maturation, detachment, and redevelopment. These biofilms can be difficult to eradicate with traditional antibiotics, leading to persistent infections and contributing to antibiotic resistance. Senna alata, a medicinal plant traditionally used for its antibacterial and antifungal properties, offers a potential natural solution to inhibit biofilm formation by pathogenic bacteria and fungi.