Antimicrobial Activity of Biodegraded Amoxicillin using Aspergillus tamarii against Escherichia coli and Staphylococcus aureus

Abstract

Antibiotic pollution in the environment has emerged as a critical issue, leading to the rise of antibiotic-resistant microorganisms. This poses a significant threat to both human health and ecological balance. The focus of this study is to investigate the potential of the filamentous fungus Aspergillus tamarii in biodegrading amoxicillin, a common β-lactam antibiotic, through enzymatic processes. The aim is to evaluate the effectiveness of A. tamarii in degrading amoxicillin and to assess the reduction in antimicrobial activity of the degraded antibiotic against Escherichia coli and Staphylococcus aureus.