Antimicrobial Activity of Endophytic Fungus Isolated from Plectranthus amboinicus

Abstract

With antimicrobial resistance (AMR) rendering many conventional antimicrobials ineffective against multidrug-resistant (MDR) pathogens, there is an urgent need for novel antimicrobial research. Compared to synthetic drugs, plant-derived compounds are often more biocompatible and environmentally sustainable, making them a valuable source. However, the yield of plant-based extract is relatively low. Endophytic fungi, are one of the potential sources of bioactive compounds with pharmaceutical properties since they can be grown at a laboratory scale. Plectranthus amboinicus is a well-documented medicinal plant with notable antibacterial activity, yet research on its antimicrobial potential remains limited. This study aims to fill this research gap and evaluate the antimicrobial activity, properties and efficacy of endophytic fungus isolated from P.amboinicus as an antimicrobial agent against clinical pathogenic microorganisms.