Lawsonia inermis Methanolic Extract: Determination of Its Phytochemicals, Antioxidants and Synergistic Effect with Fluconazole in Antifungal Treatment

Abstract

Fungal infections are becoming a global health issue, affecting over 15 million people. A common fungus involved is Candida albicans, which causes candidiasis. Overuse and misuse of antifungal drugs have led to fungi developing resistance, making treatment more difficult. Henna, known as Lawsonia inermis, is a common plant that is used in various applications such as treatments to fight infections and cosmetics with dying properties from its pigment. L. inermis is utilised to cure infections such as amebiasis, jaundice, skin problems, and headaches. Hence, the aim of the study is to determine the phytochemical and antioxidant activity of L. inermis methanolic extract as well as its synergistic effect with antifungal drug, fluconazole against C. albicans.