Characterization of Extended-Spectrum Beta-Lactamase Genes from Carbapenem Resistant Enterobacterales

Abstract

Antimicrobial resistance (AMR) is a critical global health concern, particularly with Carbapenem-Resistant Enterobacterales (CRE). Carbapenem antibiotics serve as a last line of defence against these resistant bacteria. However, the presence of Extended-Spectrum Beta-Lactamase (ESBL) enzymes, which are resistant to a broad range of beta-lactam antibiotics making the treatment harder. This study aims to identify the presence of ESBL genes in isolated CRE, focusing on Escherichia coli and Klebsiella pneumoniae from recreational water.