Characterization of Biofilm-Forming Capabilities and Potential of Tetrahydro-ꞵ-Carbolines Against Pseudomonas aeruginosa Clinical Isolates

Abstract

The genus Pseudomonas is a widespread bacterium that is recognized by its resistance to antibiotics and ability to form biofilms, which makes it difficult to eradicate. This study focuses on P. aeruginosa infections that are resistant to multiple drugs (MDR) and difficult to treat (DTR), which represent significant therapeutic problems in Malaysia. Since current antibiotics have limited effectiveness, new therapeutics are required. Tetrahydro-β-carbolines (THβCs), possible antibacterial agents against P. aeruginosa, have various pharmacological characteristics. This study utilized five strains of P.aeruginosa from Raja Permaisuri Bainun Hospital, Ipoh, Perak and three derivatives of THβCs compounds from Chemical Synthesis Group, Puncak Alam. The purpose of this study is to investigate the effect of THβCs against P. aeruginosa.