Characterization of Biofilm Forming Cabilities and the Potential of Tetrahydro-β-Carboline Against Pseudomonas aeruginosa Clinical Isolates

Abstract

Antibiotics have been utilized for over 70 years to treat bacterial infections with diverse medical applications. However, their misuse has resulted in a rapid increase in antimicrobial resistance. Pseudomonas aeruginosa is a commonly known in antimicrobial resistance worldwide which is an opportunistic pathogen associated with various infections, particularly in immunocompromised patients. The emergence of multidrug-resistant strains necessitates the exploration of new antimicrobial compounds. Tetrahydro-β-carboline (THBC) compounds have shown potential promise in inhibiting biofilm formation and bacterial growth. This study investigates the efficacy of THBC against P. aeruginosa isolated from clinical isolates in Malaysia.