Acetylcholinesterase Activity and Histopathological Effects of Caffeine in Liver of Plasmodium berghei ANKA-Infected ICR Mice

Abstract

Malaria is a disease caused by infection of Plasmodium parasite through bites of infected female Anopheles mosquitoes, and can lead to several liver damage symptoms. In humans, acetylcholinesterase (AChE) activity was found to be affected by malarial infections. The resistance of Plasmodium parasites against existing anti-malarial drugs has led to an increasing number of malarial infections. Caffeine potential as an anti-malarial drug was seen from the presence of alkaloids in caffeine compound, that can act as anti-malarial. Therefore, this study was conducted to determine the effects of caffeine on AChE activity and histopathological analysis in the liver of P. berghei ANKA-infected ICR mice.