Acetylcholinesterase Activity and Histopathological Effects of Caffeine In Brain of Plasmodium berghei ANKA-Infected ICR Mice

Authors

  • Syazliyana Sarohe School of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
  • Wan Rozianoor Mohd Hassan Human Genetic and Biochemistry, Research Nexus of UiTM (ReNeU), Universiti Teknologi MARA, Shah Alam, Selangor, Malaysia

Keywords:

Malaria, Acetylcholinesterase Activity, Histopathological Studies, Caffeine, P. berghei ANKA

Abstract

Malaria has been a global concern, recorded with 241 million cases and 627,000 deaths in 2020. It is a common and life-threatening infectious disease caused by parasites of the Plasmodium genus and transmitted by the female Anopheles mosquito. In Malaysia, cases rose to 404 in 2022, with cerebral malaria being one of the most severe complications related to malaria. Caffeine, known as an adenosine receptor antagonist, is being used as a treatment in this study to investigate its potential as an antimalarial activity. Therefore, this study aims to determine AChE activity and the histopathological effects of caffeine in the brains of P. berghei ANKA-infected ICR mice.

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Published

15-04-2025

Issue

Vol. 47 (2025): CAS 2024

Section

Articles