Molecular Dynamic Simulation of Wrightiaionoside B from Wrightia Genus Against Wild-Type And Quadruple Mutant Plasmodium falciparum Dihydrofolate Reductase (pfDHFR)

Abstract

Malaria is a life-threatening parasitic disease caused by Plasmodium, with Plasmodium falciparum being the deadliest species. Drug-resistant strains of P. falciparum have become a global challenge in malaria control. Antimalarial drugs target essential enzymes like dihydrofolate reductase (DHFR) in the parasite's metabolic pathways.