Determination of anti-acetylcholinesterase activity from the ethanolic extract of Artocarpus heterophyllus branches

Abstract

The patients with Alzheimer’s disease (AD) have a problem in maintaining longer synaptic transmission due to degeneration of cholinergic neuron which lowers the amount of acetylcholine (ACh). Less ACh and abundance of acetylcholinesterase (AChE) which hydrolyse ACh cause shorter synaptic transmission in brain. One strategy to compensate for the low level of ACh is by using acetylcholinesterase inhibitor (AChEI) with anti-AChE ability which maintains longer impulse transmission and improves AD symptoms. This study is conducted to determine the percentage yield, anti-AChE activity and bioactive compounds related to the anti-AChE activity from A. heterophyllus ethanolic extract.