A Dispersive Micro-Solid Phase Extraction Using Ionic Liquid – Modified Graphene Oxide Sorbent for Pre –Concentration and Extraction of Acid Drug From Water Sample Using Liquid Chromatography

Abstract

Pharmaceutical waste has recently been identified as a significant cause of novel toxins and a grave ecological health concern. Dispersive micro-solid phase extraction (D-μ-SPE) is a miniaturized method that adheres to the same principle as the solid phase extraction (SPE) approach, based on the dispersion of miniature or milligram level of sorbent within a solution. The advancement of dispersive micro-solid phase extraction (D-μ-SPE) has offered a novel method that is straightforward, quick, and effective. Nowadays, graphene oxide (GO), combined with ionic liquid, has found applications as sorbents for diverse purposes.