Synthesis, Characterization and Cytotoxic Activity of Betulinic Acid Glucosides against Human Myeloid Leukemia and Human T-4 Lymphoblastoid Cell Lines

Authors

Mohd Tajudin Mohd Ali
Nurhana Faujan

Keywords:

Anti-leukemia, Betulinic acid, Bisglycoside Glycosylation

Abstract

Glycosylation of betulinic acid with
-D-glucose-pentaacetate was successfully synthesized in the
presence of boron trifluoro etherate (BF3
.Et2O) in pyridine to
give betulinic acid bisglucoside in 92.8% yield. Further
treatment of bisglucosides with methanol and sodium metal
produced high polarity betulinic acid glucoside with 45%
yield. Evaluation of human myeloid leukemia cell (HL60) and
human T4-lymphoblastoid cell (CEMSS) activities with both
synthesized compounds revealed that both compounds were
less potent compared to betulinic acid itself but their water
solubility were slightly increase.

References

Published

2016-06-30

Issue

Vol. 10 No. 1 (2016): Science Letters

Section

Articles

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