Regenerative Medicine : A Promising Approach In Overcoming Diabetes As An Increasing Economic Health Burden
DOI:
https://doi.org/10.24191/jeeir.v3i2.6288Keywords:
Diabetes mellitus, beta cells, insulin, regenerative medicine, stem cellsAbstract
Diabetes mellitus is a serious public health issue, particularly in developing nations due to the cost associated with its management and its debilitating complications. Patients with diabetes mellitus type 1 are insulin-dependent due to complete loss of insulin producing beta cells in the pancreas and require a well-balanced regimen of insulin injections for life-time. The patients with diabetes mellitus type 2 also require insulin therapy in later stages of disease. In these patients insulin helps by correcting the insulin deficiency, however, the root cause of the disease still persists. Regenerative therapy is now offering solutions and hope to people with insulin-dependent diabetes. This paper gives an outline of the currently used methods in regenerative medicine that aim to re-establish the functional beta cells and restore the body’s original ability to regulate blood glucose levels.
References
Brubaker PL, Drucker DJ. Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in pancreas, gut, and central nervous system. Endocrinology 2004;145:2653–2659.
Chan JC, Malik V, Jia W, et al. Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA 2009;301:2129–2140.
Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by selfduplication rather than stem-cell differentiation. Nature 2004;429:41–46.
Hori Y, Rulifson IC, Tsai BC, Heit JJ, Cahoy JD, Kim SK. Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci USA 2002; 99:16105–16110.
Lumelsky N, Blondel,O, Laeng P, Velasco I, Ravin R, McKay R. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 2001; 292:1389– 1394.
Morrish NJ, Wang SL, Stevens LK, Fuller JH, Keen H. Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia 2001, 44 Suppl 2:S14–S21.
Nir T, Melton DA, Dor Y. Recovery from diabetes in mice by beta cell regeneration. J Clin Invest 2007;117:2553–2561.
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichifatty T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861–872.
Xu G, Stoffers DA, Habener JF, Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and genesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999; 48:2270–2276.
Zhang P, Zhang X, Brown J, et al. Global healthcare expenditure on diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010;87:293–301.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2015 Nafeeza Mohd Ismail, Renu Agarwal

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.





