Synthesis, Characterization and Biological Activity of Nitrogen­ Oxygen-Sulfur (NOS) Transition Metal Complexes Derived from Novel S-2,4-dichlorobenzyldithiocarbazate with 5-fluoroisatin

Authors

  • Mohd Abdul Fatah Abdul Manan
  • Hadariah Bahron
  • Karimah Kassim
  • Mohd Asrul Hafaz Mohamad
  • Syed Nazmi Sayed Mohamad

DOI:

https://doi.org/10.24191/srj.v7i2.9420

Keywords:

metal complexes, S-2-4dichlorobenzyldithiocarbazate, 5-fluoroisatin, Schiff base, biological activity

Abstract

A novel Schiff base containing nitrogen-oxygen-sulfur (NOS) donor atoms formed from the condensation reaction of S-2,4-dichlorobenzyldithiocarbazate (S-2,4BDTC) with 5-fluroisatin has been synthesized. Complexes of cobalt(II), nickel(II), copper(II), zinc(II) and cadmium(II) with this Schiff base have been prepared and characterized using elemental analysis and various physico-chemical techniques. In the cobalt(II) and nickel(II) complexes the Schiff base behaves as a uninegatively charged tridentate nitrogen-oxygen-sulfur (NOS) chelating ligand, bonding through the azomethine nitrogen, thiolate sulfur and carbonylic oxygen of the isatin moiety. However, in the copper(II), zinc(II) and cadmium(II) complexes the Schiff base behaves as a nitrogen-sulfur (NS) bidentate chelating ligand, bonding through the azomethine nitrogen and thiolate sulfur. The Schiff base and the metal complexes were evaluated with respect to antimicrobial activity, which was performed in relation to two selected pathogenic microbials (Bacillus subtilis and Pseudomonas aeruginosa). It was observed that only the zinc Schiff base complex exhibited strong activity against the Bacillus subtilis bacteria with an inhibition zone of 25 mm. 

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Published

2010-12-01

How to Cite

Abdul Manan, M. A. F. ., Bahron, H. ., Kassim, K. ., Mohamad, M. A. H. ., & Sayed Mohamad, S. N. . (2010). Synthesis, Characterization and Biological Activity of Nitrogen­ Oxygen-Sulfur (NOS) Transition Metal Complexes Derived from Novel S-2,4-dichlorobenzyldithiocarbazate with 5-fluoroisatin. Scientific Research Journal, 7(2), 67–90. https://doi.org/10.24191/srj.v7i2.9420

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